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KMID : 1214920140200020168
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Soonchunhyang Medical Science
2014 Volume.20 No. 2 p.168 ~ p.171
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A Case of Hepatitis B Virus Reactivation in a HBsAg-Negative and Anti-HBs-Positive Patient with Diffuse Large B-Cell Lymphoma after Rituximab plus CHOP Chemotherapy
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Park Han-Min
Seo Jae-Yong
Choi Chung-Jo
Kim Jin-Hee
Kim Bum-Joon
Jeong Yong-Seol
Park Choong-Kee
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Abstract
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The reactivation of hepatitis B virus (HBV) is well known complication among lymphoma patient related with chemotherapy. Rituximab is monoclonal antibody that targets B-lymphocytes for treatment of lymphoma and it increases reactivation of HBV. Although most of reactivation occurs in HBV carrier, it can also rarely occur when hepatitis B surface antigen (HBsAg) is negative. Furthermore it is less frequently reported in lymphoma patient when HBV serology shows HBsAg is negative and anti-HBs is positive. We report a case of HBV reactivation following 6 cycle of rituximab plus CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy for diffuse large B-cell lymphoma in HBsAg negative/anti-HBs positive 58-year-old male, with a review of the literature.
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KEYWORD
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Hepatitis B virus, Lymphoma, Rituximab
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